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Best Hangover Pills of 2024: Remedies and Prevention Worth the Hype

Dreading waking up with a pounding headache after a night out drinking? As you get older, your body may not be able to handle alcohol as well as it used to. This guide takes a look at the best hangover pills like Myrkl and how they can help prevent hangover symptoms—like tiredness, nausea, and “hangxiety.” Let’s find the right hangover remedy for your needs!

Best Hangover Pills in 2024

What Are Hangover Pills?

Hangover pills are dietary supplements aiming to alleviate the usual hangover symptoms caused by drinking too much alcohol. These include headaches, nausea, fatigue, and dehydration. Anti-hangover pills typically come with vitamins, minerals, and herbal extracts that may help you bounce back faster.

 

These supplements generally improve liver function, detoxify your system, and replenish essential nutrients. The best hangover pills speed up your body’s recovery process, allowing you to feel better the day after drinking.

 

There are different types available—from the best charcoal pills for hangover you can take any time to drinks you should chug down before you go out. Still, they have a common goal: to break down alcohol in your body more efficiently.

 

Some work with a combination of pain relievers and stimulants; others focus on replenishing electrolytes or emphasize detoxification through herbal extracts.

Do Hangover Pills Work?

Hangover pills may help alleviate some symptoms of a hangover by addressing the common causes, such as dehydration, nutrient depletion, and toxin buildup. The ingredients we’ve discussed above may support your liver function and detoxification, help restore energy, and retain hydration levels. 

 

By replenishing nutrients and promoting faster metabolism of different types of alcohol, the best hangover pills could make these symptoms less severe and hasten your recovery. However, they don’t always work for everyone; individual factors, such as your metabolism and how much alcohol you consume, will play a role in how effective it will be for you. 

 

Some folks find much relief from hangover symptoms through these supplements, while others may notice little to no improvement. Keep in mind that hangover pills cannot completely prevent the damage caused by excessive alcohol consumption; that’s why you should always drink responsibly.

 

1. Myrkl – Best Hangover Pills Overall

Myrkl-

Pros

  • Contains natural, vegan-friendly ingredients
  • Improves your alcohol metabolism
  • Makes you feel less tired the next day
  • Supports your liver health

Cons

  • Not for minors

Overview

Why is Myrkl our favorite among the best hangover pills? Well, it’s a proactive solution to prevent hangovers, claiming to break down up to 70% of alcohol within an hour. This anti-hangover pill can come in handy for regular drinkers who wish to avoid fatigue and other symptoms (or recover faster from them).

Pricing

A pack of 15 servings—or 30 capsules—costs $35.99, and you can subscribe to save 20% on all purchases. Additionally, the official website often features discounts on bulk purchases.

Key Ingredients

The star ingredients inside Myrkl are l-cysteine and vitamin B12. L-cysteine is a high-performing bacteria that helps break down alcohol into water and carbon dioxide to keep your body from making too much acetaldehyde [1]. Aside from probiotics, vitamin B12 may also help amp up your energy levels [2] and combat tiredness.

User Reviews

Many users share positive feedback about Myrkl and how it works. As an example of praise for these top hangover pills, one Redditor claims they helped them lessen the pain [3]. On the other hand, another Reddit user says in r/Ireland that it’s not a miracle cure while admitting that it does help a little [4].

>>Find the best price for Myrkl here

2. BetterMorning by BetterBrand – Best for “Hangxiety”

BetterMorning - BetterBrand-

Pros

  • Composed of herbal extracts and other natural ingredients
  • Keeps you from feeling anxious after drinking
  • Contains antioxidants and anti-inflammatory agents
  • Flushes out toxins from your liver

Cons

  • You can only return unopened bottles

Overview

BetterBrand’s BetterMorning keeps you from feeling anxious and dizzy the day after by reducing the impact of alcohol. These best pills for hangovers also promise to relieve other symptoms—like headaches and morning nausea.

Pricing

A 42-capsule bottle of BetterMorning (which is worth 14 servings) is priced at $29.95 if you make a one-time purchase. If you like it, you can subscribe and get future supplies for $23.96.

Key Ingredients

The main ingredients in BetterMorning include milk thistle, ginger root, ALA, and B vitamins. Milk thistle could help detoxify your liver and make it less inflamed [5], while ginger enhances your digestive health [6]. 

User Reviews

Many users give BetterMorning a thumbs-up in their reviews. Many users swear by it and claim it does exactly what it promises [7]. However, not all reviewers enjoyed such benefits and some felt it made things worse the morning after [8].

>>Find the best price for BetterMorning here

3. Flyby Recovery Capsules – Best Hangover Pills for Recovery

Flyby Recovery Capsules-

Pros

  • Speeds up your post-drinking recovery
  • Supplies essential nutrients
  • Improves your liver health
  • Rehydrates your body

Cons

  • Proprietary blend doesn’t list the amount of some ingredients

Overview

Flyby Recovery Capsules help you bounce back quickly the day after your drinking session. Taken before or after drinking, these best anti-hangover pills restore your nutrients—through a blend of vitamins, minerals, and herbal extracts—that enhance liver function and hydration.

Pricing

Flyby Recovery Capsules cost $34.97 for an 80-capsule bottle. You can subscribe to save 15% on all purchases, such as the lower price of $29.72 for a single bottle.

Key Ingredients

The active ingredients include DHM (dihydromyricetin), milk thistle, n-acetyl cysteine, and vitamins B plus C. If DHM could help detoxify your liver [9], then cysteine may tone down alcohol’s effect on your body [10]. Also, B vitamins replenish the nutrients you lose while drinking [2].

User Reviews

Marketed with a “party hard, recover harder” catchphrase, Flyby Recovery Capsules has received more than its fair share of positive feedback from customers. Many claim they work as they should and are a perfect solution on the go [11]. Negative feedback mostly revolves around mold in bottles before the expiry date [12]. 

>>Find the best price for Flyby Recovery Capsules here

4. H-PROOF The Anytime You Drink Vitamin – Best for On-the-Go Use

The Anytime You Drink Vitamin - H-Proof-

Pros

  • Delivers essential vitamins and antioxidants
  • Easy to take anytime, anywhere
  • Boosts your liver health
  • You can choose from different flavors

 

Cons

  • Pricey

Overview

H-PROOF’s convenient, chewable tablets are the best anti-hangover pills you can quickly pop even if you’re traveling. This anti-hangover pill provides vitamins and minerals, assisting your liver to work properly and reducing hangover symptoms.

Pricing

The Anytime You Drink Vitamin costs $59 for a pack of 40 tablets, which stands for 20 servings.

Key Ingredients

The formula includes a proprietary liver support blend with silymarin and taurine, vitamins C and E, magnesium, zinc, folate, riboflavin, and several B vitamins. Whereas vitamin C encourages your body’s natural detoxification processes [13], minerals like zinc and magnesium may keep you hydrated [14] and replenish those nutrients.

User Reviews

So far, the Anytime You Drink Vitamin has received mostly good feedback from customers. Users generally report that it helps them feel sober very quickly [15], and those who don’t find it effective praise the company for offering refunds [16].

>>Find the best price for The Anytime You Drink Vitamin here

5. Cheers Restore – Best for Relaxation

Cheers Restore-

Pros

  • Helps prevent GABA withdrawal
  • Encourages liver detoxification
  • Rehydrates your system
  • Transparent ingredient list

Cons

  • Complex return process

Overview

Cheers Restore could be the best hangover pills if you hope to reduce GABA rebound. By working as you sleep, it allows you to feel more relaxed (instead of irritable). Thanks to its blend of vitamins, electrolytes, and antioxidants, it aids your liver in getting rid of toxins and replenishes those missing nutrients.

Pricing

Cheers Restore costs $34.99 for a 36-capsule bottle, which is equal to 12 servings.

Key Ingredients

The vital ingredients in Cheers hangover pills include DHM, milk thistle, prickly pear, and a variety of vitamins and electrolytes. DHM may help cleanse your liver, as well as support alcohol metabolism and hydration [9]. Plus, milk thistle may bring down swelling [5].

User Reviews

These hangover pills earned a lot of positive feedback from customers. In r/alcohol, for instance, a Reddit user says that this anti-hangover pill works wonders [17]. On the other end of the spectrum, another Reddit commenter on r/supplements thinks it might just have a placebo effect, even though it did help her the two times she took it [18].

>>Find the best price for Cheers Restore here

6. AFTERDRINK – Best Hangover Pills for Detoxification

AFTERDRINK - Omre-

Pros

  • Prevents the build-up of toxins
  • Made from natural ingredients with optimal doses
  • Enhances liver health and hydration
  • Caffeine-free and vegan-friendly

Cons

  • You’re supposed to take 6 capsules 

Overview

While many of the best hangover pills aim to detoxify your liver, AFTERDRINK has an edge in this area; after all, it doesn’t come with any fillers that may last longer than how long alcohol actually stays in your system. Plus, the formula features 23 herbal extracts to keep you hydrated and well-nourished.

Pricing

AFTERDRINK is priced at $34.97 for a 48-capsule bottle (or 16 servings), with small discounts available if you buy multiple bottles.

Key Ingredients

The primary ingredients in AFTERDRINK are milk thistle, prickly pear, ginger root, and essential vitamins. Since the goal is liver detoxification, milk thistle reduces swelling and flushes out toxins [5]. Additionally, the nutrients help your body recover faster.

User Reviews

Many users report positive results after using AFTERDRINK. Some report superb results after a heavy night out, while others claim it works like a charm every time [19][20]. Few users report experiencing no effects after trying it [21].

>>Find the best price for AFTERDRINK here

7. Drinkwel – Best Pills for Hangover Headaches

drinkwel Better Mornings-

Pros

  • May help relieve headaches the next day
  • Bolsters liver health
  • Packed with nutrients
  • Eliminates toxins

Cons

  • No exact ingredient amounts are listed for the proprietary blends

Overview

Drinkwel works great as the best pill for hangover headaches, as it features a comprehensive mix of vitamins, minerals, and herbal extracts. These best hangover pills also boost your overall health and liver function, ultimately making it less likely that you’ll experience headaches—or other hangover symptoms— after you enjoy drinking.

Pricing

You can order a 30-capsule bottle of Drinkwel for $19.99; you can also save a little by purchasing larger packs.

Key Ingredients

Some crucial ingredients are milk thistle, DHM, plus B vitamins. Milk thistle could help your liver process harmful toxins [5]. Additionally, the formula rejuvenates your body through essential nutrients, which could address some of the causes of hangover headaches.

User Reviews

Many users have good things to say about Drinkwel. To illustrate, on r/hangover, one Reddit user relays that these hangover pills make it possible for her to function and get stuff done the next day [22]. However, there’s also a Redditor who thinks it’s too expensive and just doesn’t work for them [23]. 

>>Find the best price for Drinkwel here

8. Purple Tree – Best Hangover Pills for Flexibility

purpletree Post-Celebration Wellness Vitamins-

Pros

  • Versatile ways to use it
  • Uplifts your liver wellness
  • Supports hydration and electrolytes 
  • Double-tested formula

Cons

  • Proprietary blend dosages aren’t transparent

Overview

When it comes to flexibility, Purple Tree excels among the best hangover pills; you can use them not just as pre-harover pills but also during or after your drinking sessions. This supplement features natural ingredients that promote liver health and hydration to uplift your well-being.

Pricing

If a 30-capsule bottle costs $19.95, then a 60-capsule container is priced at $34.95. Yet, you’ll save the most by investing in a 180-capsule bottle for $79.95.

Key Ingredients

DHM, milk thistle (which detoxifies the liver [5]), and vitamins B1, B6, and B12 (which fight fatigue) are some of the major ingredients in these best anti-hangover pills [2].

User Reviews

Purple Tree earned a lot of positive feedback from customers. For instance, a Redditor on r/Biohacks praises it and claims it helps both him and his wife [24]. Many Trustpilot reviews also claim the pills work for them despite being pricey [25]

>>Find the best price for Purple Tree here

9. Blowfish Wingman – Fastest-Acting Anti Hangover Pills

Blowfish Wingman-

Pros

  • Promises to work in around 15 minutes
  • Supplies you with vitamins and electrolytes
  • Offers an energy boost and pain relief 
  • Zero caffeine

Cons

  • Some users find the aftertaste unpleasant

Overview

Blowfish hangover pills claim to act quickly after you take them, so you won’t be bothered too long by aches and tiredness the next day. The fusion of vitamins and electrolytes keeps you hydrated and energized. It also supports alcohol metabolism and features soothing natural extracts to help you have a better morning after a heavy night of drinking.

Pricing

Blowfish Wingman is available in 30-capsule bottles, which you can buy for $17.99.

Key Ingredients

Blowfish hangover pills feature DHM, which protects your liver [9], and l-cysteine, which assists in breaking down alcohol [1]. They also contain vitamins B2, B6, and B12, milk thistle, ginger root, and prickly pear.

User Reviews

Many Blowfish Wingman users share positive experiences about it. Many call it the ultimate life saver that takes away hangovers within half an hour [26] and claims it works wonders [27]. However, it’s not all one-sided, and some users just didn’t get any results to show [28]. 

>>Find the best price for Blowfish Wingman here

Are Hangover Pills Safe?

Generally, hangover pills are safe for most healthy adults when taken as directed. They typically contain ingredients commonly found in supplements, many of which have been deemed safe for consumption. 

 

However, the FDA does not check or approve these products. To make sure it won’t interact with your medications or worsen your health conditions, it’s a good idea to talk to your doctor before you try taking any new supplement. This is a great way to pinpoint which of the best hangover prevention pills fits your needs. 

 

Lastly, look for products from reputable manufacturers that use high-quality and well-researched ingredients, check for third-party testing, and find real user reviews that support the manufacturer’s claims. These include feedback about the best hangover pills Reddit users post on forums.

Side Effects of Hangover Pills

The side effects are few and far between with the best hangover pills, but we discuss some of the common ones below.

Gastrointestinal Discomfort

Some people experience stomach upset, nausea, or diarrhea when taking hangover pills. This can be due to high doses of vitamins or herbal extracts like milk thistle and prickly pear. Follow the recommended dosage and take your pills with food to minimize these effects. Of course, don’t take the pills anymore if it becomes unbearable. 

Allergic Reactions

While rare, allergic reactions to ingredients in hangover pills are possible. Symptoms may include rash, itching, swelling, dizziness, or difficulty breathing. Stop using it right away and seek medical attention immediately if you see any of these signs.

Interactions With Medications

Hangover pills may interact with other meds you are taking, potentially affecting their effectiveness or increasing the risk of side effects. Always consult a healthcare professional before combining hangover pills with other medications.

How to Responsibly Use Hangover Pills

Let’s move on and discuss what you can do to ensure safety when taking pre-hangover pills.

Consult a Healthcare Provider

If you’re planning to take a new supplement, discuss it with your doctor first. A healthcare professional can provide personalized advice based on your health history and current medications, ensuring the hangover pill is safe and appropriate for you.

Follow the Recommended Dosage

Stick to the recommended dosage on the product label to avoid potential side effects. Taking more than the advised amount will not necessarily enhance the effectiveness; instead, it could increase the risk of adverse reactions.

Use as Part of a Broader Strategy

Don’t solely rely on hangover pills to manage your hangovers. Use them together with other healthy habits—such as staying hydrated, eating nutritious meals, and getting enough rest.

Avoid Excessive Alcohol Consumption

Hangover pills are not a license to drink excessively. After all, they are meant to mitigate the effects of moderate alcohol consumption. Drinking responsibly and knowing your limits is key to preventing severe hangovers and long-term health issues.

Choose Reputable Products

Are you wondering where to buy hangover pills? Choose supplements from reputable manufacturers that provide transparent ingredient lists and undergo third-party testing. Buying from official stores ensures you are getting a high-quality product that is both generally safe and potentially effective.

Additional Tips for Preventing Hangovers

Aside from taking the best hangover pills, you want to try and do your bit in battling hangovers in the first place. Here are some of the things you can do.

Pace Yourself

Drinking alcohol at a slower pace gives your body more time to metabolize the alcohol, reducing the burden on your liver. The liver can process around one standard drink per hour, so spacing your drinks can help keep your blood alcohol at a manageable level. This prevents rapid spikes in concentration and grants you a better chance to stay hydrated​.

Stay Hydrated

Alcohol is a diuretic, which means it increases urine production. This can lead to dehydration and contribute to symptoms like headaches and dizziness. Drink plenty of water before, during, and after drinking alcohol to stay hydrated. A good rule of thumb is to chase each alcoholic drink with a glass of water.

Avoid Carbonated Drinks

Carbonated beverages like soda mixers accelerate the absorption of alcohol into the bloodstream. They speed up the passage of alcohol from your stomach to your small intestine, where it is absorbed more quickly. This can lead to higher blood alcohol concentration levels in a shorter period, ultimately increasing the likelihood of a hangover.

Eat Before Drinking

Munching on some food before drinking alcohol can greatly reduce your hangover. Food slows the absorption of alcohol and allows it to be metabolized gradually. Meals rich in carbohydrates, proteins, and fats are particularly effective in stabilizing your blood sugar levels and slowing the absorption of alcohol.

Avoid Smoking

Smoking while drinking can increase hangover symptoms; nicotine and other chemicals increase the rate at which your body metabolizes alcohol. This leads to higher BAC levels, aside from contributing to dehydration.

Get Adequate Sleep

Alcohol can disrupt your sleep cycle, leading to poor-quality rest. Make sure you get enough sleep after a night out to help your body recover faster. Keep as close to your regular sleep schedule as possible.

FAQs About Best Hangover Pills

We address some of the most commonly asked questions on hangover pills and how they work below. 

What Is the Best Hangover Reliever?

There is no single “best” hangover pill, as the experiences of each user often vary. Products like Myrkl and BetterBrand’s BetterMorning are highly rated among users on Reddit and other platforms, but you should consider your needs and metabolism first.

What Medicine Is Good for a Hangover?

Over-the-counter pain relievers like ibuprofen or aspirin could help alleviate headaches. You should avoid acetaminophen (a.k.a. paracetamol), though, as it can be harsh on the liver, especially after alcohol. FDA-approved alcohol medication treatments might benefit you in case you have an alcohol use disorder.

Is There a Pill to Stop a Hangover?

While no pill can completely prevent a hangover, some supplements can really help reduce symptom severity. They aim to reduce alcohol’s impact and help your body battle its symptoms.

How Much Do Hangover Pills Cost?

There are many hangover pills, and the cost will depend on the brand you choose, the ingredients inside, and, ultimately, its popularity in the long run. On average, a bottle with 20 servings costs anywhere from about $20 to $60.

Final Thoughts on the Best Hangover Pills

The best hangover pills make for better mornings after. The top products like Myrkl have probably made thousands of mornings more bearable, but you should make sure you always use them as no more than supplements! Make sure you also sleep well, eat well, stay hydrated, and – most importantly – enjoy alcohol responsibly!

>>Get rid of those nasty hangovers – try Myrkl now! 

References

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  11. “Frédérique gave Flyby Recovery Pill 5 Stars”, Amazon. https://www.amazon.com/gp/customer-reviews/RYISH2EMGAYM5/ref=cm_cr_getr_d_rvw_ttl?ie=UTF8&ASIN=B078YCFZ3F. Accessed 10 Sept. 2024. 
  12. “Rachel D gave Flyby Recovery Pill 3 Stars”, Amazon. https://www.amazon.com/gp/customer-reviews/R11UBEA5IFVD8L/ref=cm_cr_getr_d_rvw_ttl?ie=UTF8&ASIN=B078YCFZ3F. Accessed 10 Sept. 2024. 
  13. Akram NA, Shafiq F, Ashraf M. Ascorbic Acid-A Potential Oxidant Scavenger and Its Role in Plant Development and Abiotic Stress Tolerance. Front Plant Sci. 2017 Apr 26;8:613. doi: 10.3389/fpls.2017.00613. PMID: 28491070; PMCID: PMC5405147.
  14. Hamedifard Z, Farrokhian A, Reiner Ž, Bahmani F, Asemi Z, Ghotbi M, Taghizadeh M. The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. Lipids Health Dis. 2020 May 28;19(1):112. doi: 10.1186/s12944-020-01298-4. PMID: 32466773; PMCID: PMC7257447.
  15. “Tim Atkinson gave H-PROOF The Anytime You Drink 5 Stars”, Amazon. https://www.amazon.com/gp/customer-reviews/R17F4940AIB030/ref=cm_cr_dp_d_rvw_ttl?ie=UTF8&ASIN=B09P1S6VKG. Accessed 10 Sept. 2024. 
  16. “Nicole gave H-PROOF The Anytime You Drink 4 Stars”, Amazon. https://www.amazon.com/gp/customer-reviews/R12ZJ1CHIBYVQD/ref=cm_cr_dp_d_rvw_ttl?ie=UTF8&ASIN=B09P1S6VKG. Accessed 10 Sept. 2024. 
  17. R/Alcohol on Reddit: Best Hangover Remedy 2023? (opinions), https://www.reddit.com/r/alcohol/comments/10hh9hm/comment/l60y0n9/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button. Accessed 10 Sept. 2024.
  18. R/Supplements on Reddit: Has anyone tried “cheers” it’s like an alcohol aid for hangovers?, https://www.reddit.com/r/Supplements/comments/cyj8kz/comment/eyslywz/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button. Accessed 10 Sept. 2024.
  19. “Nyles Thorne gave AfterDrink 5 Stars”, Trustpilot. https://www.trustpilot.com/reviews/61071c8df9f48709d4c53335. Accessed 10 Sept. 2024. 
  20. “Kourosh gave AfterDrink 5 Stars”, Trustpilot. https://www.trustpilot.com/reviews/590b960ba02b4205fc035dac. Accessed 10 Sept. 2024. 
  21. “Sahbi Sahbi gave AfterDrink 3 Stars”, Trustpilot. https://www.trustpilot.com/reviews/5f4e2b9002e8570814fd508d. Accessed 10 Sept. 2024. 
  22. R/hangover on Reddit: Hangover Pills, https://www.reddit.com/r/hangover/comments/exd8fv/comment/fiyjadv/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button. Accessed 10 Sept. 2024.
  23. R/keto on Reddit: Has anybody ever used Drinkwel, https://www.reddit.com/r/keto/comments/4mv5hn/comment/d3yl8jw/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button. Accessed 10 Sept. 2024.
  24. R/Biohackers on Reddit: Hangover treatment?, https://www.reddit.com/r/Biohackers/comments/17sw5zc/comment/k8t2zjo/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button. Accessed 10 Sept. 2024.
  25. “Lilah gave Purple Tree Labs 5 Stars”, Trustpilot. https://www.trustpilot.com/reviews/66a28237dc245dba5ed31371. Accessed 10 Sept. 2024. 
  26. “Jillian stach gave Blowfish Complete Hangover System 5 Stars”, Amazon. https://www.amazon.com/gp/customer-reviews/R2FCRX7MUUKWRW/ref=cm_cr_arp_d_rvw_ttl?ie=UTF8&ASIN=B0CQKQ3VWP. Accessed 10 Sept. 2024. 
  27. “Ezra Wagener gave Blowfish Complete Hangover System 5 Stars”, Amazon. https://www.amazon.com/gp/customer-reviews/R40CZPRA47AIP/ref=cm_cr_arp_d_rvw_ttl?ie=UTF8&ASIN=B0CQKQ3VWP. Accessed 10 Sept. 2024. 
  28. “Maggie gave Blowfish Complete Hangover System 1 Stars”, Amazon. https://www.amazon.com/gp/customer-reviews/RYXS82FR16U17/ref=cm_cr_getr_d_rvw_ttl?ie=UTF8&ASIN=B0CQKQ3VWP. Accessed 10 Sept. 2024. 
  29. Madrigal-Santillán, E., García-Melo, F., Morales-González, J., Vázquez-Alvarado, P., Muñoz-Juárez, S., Zuñiga-Pérez, C., Sumaya-Martínez, M., Madrigal-Bujaidar, E., & Hernández-Ceruelos, A. (2013). Antioxidant and Anticlastogenic Capacity of Prickly Pear Juice. Nutrients, 5(10), 4145–4158. https://doi.org/10.3390/nu5104145
  30. National Research Council (US) Subcommittee on the Tenth Edition of the Recommended Dietary Allowances. (2016). Water and Electrolytes. Nih.gov; National Academies Press (US). https://www.ncbi.nlm.nih.gov/books/NBK234935/
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